- 106 – Start of the Bostran era, the calendar of the province of Arabia Petraea.
- 238 – Gordian I and his son Gordian II are proclaimed Roman emperors.
- 871 – Æthelred of Wessex is defeated by a Danish invasion army at the Battle of Marton.
- 1508 – Ferdinand II of Aragon commissions Amerigo Vespucci chief navigator of the Spanish Empire.
- 1621 – The Pilgrims of Plymouth Colony sign a peace treaty with Massasoit of the Wampanoags.
- 1622 – Jamestown massacre: Algonquians kill 347 English settlers around Jamestown, Virginia, a third of the colony’s population, during the Second Anglo-Powhatan War.
- 1630 – The Massachusetts Bay Colony outlaws the possession of cards, dice, and gaming tables.
- 1638 – Anne Hutchinson is expelled from Massachusetts Bay Colony for religious dissent.
- 1713 – The Tuscarora War comes to an end with the fall of Fort Neoheroka, effectively opening up the interior of North Carolina to European colonization.
- 1739 – Nader Shah occupies Delhi in India and sacks the city, stealing the jewels of the Peacock Throne.
- 1765 – The British Parliament passes the Stamp Act that introduces a tax to be levied directly on its American colonies.
- 1784 – The Emerald Buddha is moved with great ceremony to its current location in Wat Phra Kaew, Thailand.
- 1829 – In the London Protocol, the three protecting powers (United Kingdom, France and Russia) establish the borders of Greece.
- 1849 – The Austrians defeat the Piedmontese at the Battle of Novara.
- 1871 – In North Carolina, William Woods Holden becomes the first governor of a U.S. state to be removed from office by impeachment.
- 1872 – Illinois becomes the first state to require gender equality in employment.
- 1873 – The Spanish National Assembly abolishes slavery in Puerto Rico.
- 1894 – The first playoff game for the Stanley Cup starts.
- 1906 – The first England vs France rugby union match is played at Parc des Princes in Paris
- 1920 – Azeri and Turkish army soldiers with participation of Kurdish gangs attacked the Armenian inhabitants of Shushi (Nagorno Karabakh).
- 1933 – Cullen–Harrison Act: President Franklin Roosevelt signs an amendment to the Volstead Act, legalizing the manufacture and sale of “3.2 beer” (3.2% alcohol by weight, approximately 4% alcohol by volume) and light wines.
- 1939 – Germany takes Memel from Lithuania.
- 1942 – World War II: In the Mediterranean Sea, the Royal Navy confronts Italy’s Regia Marina in the Second Battle of Sirte.
- 1943 – World War II: The entire village of Khatyn (in what is the present-day Republic of Belarus) is burnt alive by Schutzmannschaft Battalion 118.
- 1945 – World War II: The city of Hildesheim, Germany heavily damaged in a British air raid, though it had little military significance and Germany was on the verge of final defeat.
- 1945 – The Arab League is founded when a charter is adopted in Cairo, Egypt.
- 1960 – Arthur Leonard Schawlow and Charles Hard Townes receive the first patent for a laser.
- 1972 – The United States Congress sends the Equal Rights Amendment to the states for ratification.
- 1972 – In Eisenstadt v. Baird, the United States Supreme Court decides that unmarried persons have the right to possess contraceptives.
- 1975 – A fire at the Browns Ferry Nuclear Power Plant in Decatur, Alabama causes a dangerous reduction in cooling water levels.
- 1978 – Karl Wallenda of The Flying Wallendas dies after falling off a tight-rope suspended between two hotels in San Juan, Puerto Rico.
- 1982 – NASA’s Space Shuttle Columbia is launched from the Kennedy Space Center on its third mission, STS-3.
- 1992 – USAir Flight 405 crashes shortly after takeoff from New York City’s LaGuardia Airport, leading to a number of studies into the effect that ice has on aircraft.
- 1992 – Fall of communism in Albania: The Democratic Party of Albania wins a decisive majority in the parliamentary election.
- 1993 – The Intel Corporation ships the first Pentium chips (80586), featuring a 60 MHz clock speed, 100+ MIPS, and a 64 bit data path.
- 1995 – Cosmonaut Valeri Polyakov returns to earth after setting a record of 438 days in space.
- 1997 – Tara Lipinski, aged 14 years and nine months, becomes the youngest women’s World Figure Skating Champion.
- 2004 – Ahmed Yassin, co-founder and leader of the Palestinian Sunni Islamist group Hamas, two bodyguards, and nine civilian bystanders are killed in the Gaza Strip when hit by Israeli Air Force Hellfire missiles.
- 2006 – Three Christian Peacemaker Team (CPT) hostages are freed by British forces in Baghdad after 118 days of captivity and the murder of their colleague from the U.S., Tom Fox.
- 2013 – At least 37 people are killed and 200 are injured after a fire destroys a camp containing Burmese refugees near Ban Mae, Thailand.
- 2016 – Three suicide bombers kill 32 people and injure 316 in the 2016 Brussels bombings at the airport and at the Maelbeek/Maalbeek metro station.
- 2017 – A terrorist attack in London near the Houses of Parliament leaves four people dead and at least 20 injured.
- 2019 – Robert S. Mueller III delivers his report on the Russian government’s influence on the election of Donald Trump in the 2016 United States presidential election.
- 2019 – Two buses crashes in Kitampo, a town north of Ghana’s capital Accra, killing at least 50 people.
- 2020 – Indian Prime Minister Narendra Modi announces the country’s largest ever self-imposed curfew, in an effort to fight the spread of COVID-19.
Births on March 22
- 841 – Bernard Plantapilosa, Frankish son of Bernard of Septimania (d. 885)
- 875 – William I, Duke of Aquitaine (d. 918)
- 1212 – Emperor Go-Horikawa of Japan (d. 1235)
- 1367 – Thomas de Mowbray, 1st Duke of Norfolk, English politician, Earl Marshal of the United Kingdom (probable; d. 1399)
- 1394 – Ulugh Beg, Persian astronomer and mathematician (d. 1449)
- 1459 – Maximilian I, Holy Roman Emperor (d. 1519)
- 1499 – Johann Carion, German astrologer and chronicler (d. 1537)
- 1503 – Antonio Francesco Grazzini, Italian author and educator (d. 1583)
- 1517 – Gioseffo Zarlino, Italian composer (d. 1590)
- 1519 – Catherine Brandon, Duchess of Suffolk, English noblewoman (d. 1580)
- 1582 – John Williams, Archbishop of York (d. 1650)
- 1599 – Anthony van Dyck, Flemish-English painter and etcher (d. 1641)
- 1609 – John II Casimir Vasa, Polish king (d. 1672)
- 1615 – Katherine Jones, Viscountess Ranelagh, British scientist (d. 1691)
- 1663 – August Hermann Francke, German clergyman, philanthropist, and scholar (d. 1727)
- 1684 – William Pulteney, 1st Earl of Bath, English politician, Secretary at War (d. 1764)
- 1712 – Edward Moore, English poet and playwright (d. 1757)
- 1720 – Nicolas-Henri Jardin, French architect, designed the Yellow Palace and Bernstorff Palace (d. 1799)
- 1723 – Charles Carroll, American lawyer and politician (d. 1783)
- 1728 – Anton Raphael Mengs, German painter and theorist (d. 1779)
- 1785 – Adam Sedgwick, English scientist (d. 1873)
- 1797 – William I, German Emperor (d. 1888)
- 1808 – Caroline Norton, English feminist, social reformer, and author (d. 1877)
- 1808 – David Swinson Maynard, American physician and lawyer (d. 1873)
- 1812 – Stephen Pearl Andrews, American author and activist (d. 1886)
- 1814 – Thomas Crawford, American sculptor, designed the Statue of Freedom (d. 1857)
- 1817 – Braxton Bragg, American general (d. 1876)
- 1818 – John Ainsworth Horrocks, English-Australian explorer, founded Penwortham (d. 1846)
- 1822 – Ahmed Cevdet Pasha, Ottoman sociologist, historian, scholar, statesman and jurist (d. 1895)
- 1842 – Mykola Lysenko, Ukrainian pianist, composer, and conductor (d. 1912)
- 1846 – Randolph Caldecott, English illustrator and painter (d. 1886)
- 1846 – James Timberlake, American lieutenant, police officer, and farmer (d. 1891)
- 1852 – Otakar Ševčík, Czech violinist and educator (d. 1934)
- 1852 – Hector Sévin, French cardinal (d. 1916)
- 1855 – Dorothy Tennant, British painter (d. 1926)
- 1857 – Paul Doumer, French mathematician, journalist, and politician, 14th President of France (d. 1932)
- 1866 – Jack Boyle, American baseball player and umpire (d. 1913)
- 1868 – Robert Andrews Millikan, American colonel and physicist, Nobel Prize laureate (d. 1953)
- 1869 – Tom McInnes, Scottish-English footballer (d. 1939)
- 1873 – Ernest Lawson, Canadian-American painter (d. 1939)
- 1880 – Ernest C. Quigley, Canadian-American football player and coach (d. 1960)
- 1884 – Arthur H. Vandenberg, American journalist and politician (d. 1951)
- 1884 – Lyda Borelli, Italian actress (d. 1959)
- 1885 – Aryeh Levin, Polish-Lithuanian rabbi and educator (d. 1969)
- 1886 – August Rei, Estonian lawyer and politician, Head of State of Estonia (d. 1963)
- 1887 – Chico Marx, American actor (d. 1961)
- 1890 – George Clark, American race car driver (d. 1978)
- 1892 – Charlie Poole, American country banjo player (d. 1931)
- 1892 – Johannes Semper, Estonian poet and scholar (d. 1970)
- 1896 – He Long, Chinese general and politician, 1st Vice Premier of the People’s Republic of China (d. 1969)
- 1896 – Joseph Schildkraut, Austrian-American actor (d. 1964)
- 1899 – Ruth Page, American ballerina and choreographer (d. 1991)
- 1901 – Greta Kempton, Austrian-American painter (d. 1991)
- 1902 – Johannes Brinkman, Dutch architect, designed the Van Nelle Factory (d. 1949)
- 1902 – Madeleine Milhaud, French actress and composer (d. 2008)
- 1903 – Bill Holman, American cartoonist (d. 1987)
- 1907 – James M. Gavin, American general and diplomat, United States Ambassador to France (d. 1990)
- 1908 – Jack Crawford, Australian tennis player (d. 1991)
- 1908 – Louis L’Amour, American novelist and short story writer (d. 1988)
- 1909 – Gabrielle Roy, Canadian author and educator (d. 1983)
- 1910 – Nicholas Monsarrat, English sailor and author (d. 1979)
- 1912 – Wilfrid Brambell, Irish actor and performer (d. 1985)
- 1912 – Karl Malden, American actor (d. 2009)
- 1912 – Agnes Martin, Canadian-American painter and educator (d. 2004)
- 1912 – Leslie Johnson, English race car driver (d. 1959)
- 1913 – Tom McCall, American journalist and politician, 30th Governor of Oregon (d. 1983)
- 1913 – Lew Wasserman, American businessman and talent agent (d. 2002)
- 1913 – James Westerfield, American actor (d. 1971)
- 1914 – John Stanley, American author and illustrator (d. 1993)
- 1914 – Donald Stokes, Baron Stokes, English businessman (d. 2008)
- 1917 – Virginia Grey, American actress (d. 2004)
- 1917 – Irving Kaplansky, Canadian-American mathematician and academic (d. 2006)
- 1917 – Paul Rogers, English actor (d. 2013)
- 1918 – Cheddi Jagan, Guyanese politician, 4th President of Guyana (d. 1997)
- 1919 – Bernard Krigstein, American illustrator (d. 1990)
- 1920 – James Brown, American actor and singer (d. 1992)
- 1920 – Werner Klemperer, German-American actor (d. 2000)
- 1920 – Lloyd MacPhail, Canadian businessman and politician, 23rd Lieutenant Governor of Prince Edward Island (d. 1995)
- 1920 – Fanny Waterman, English pianist and educator, founded the Leeds International Pianoforte Competition
- 1920 – Katsuko Saruhashi, Japanese geochemist (d. 2007)
- 1920 – Ross Martin, American actor (d. 1981)
- 1921 – Nino Manfredi, Italian actor, director, and screenwriter (d. 2004)
- 1922 – John J. Gilligan, American lieutenant and politician, 62nd Governor of Ohio (d. 2013)
- 1922 – Stewart Stern, American screenwriter (d. 2015)
- 1923 – Marcel Marceau, French mime and actor (d. 2007)
- 1924 – Al Neuharth, American journalist and author, founded USA Today (d. 2013)
- 1924 – Yevgeny Ostashev, Russian test pilot, participant in the launch of the first artificial Earth satellite (d. 1960)
- 1924 – Osman F. Seden, Turkish director, producer, and screenwriter (d. 1998)
- 1924 – Bill Wendell, American television announcer (d. 1999)
- 1927 – Marty Blake, American basketball player and manager (d. 2013)
- 1927 – Nicolas Tikhomiroff, Russian photographer (d. 2016)
- 1928 – Carrie Donovan, American journalist (d. 2001)
- 1928 – E. D. Hirsch, American author, critic, and academic
- 1928 – Ed Macauley, American basketball player, coach, and priest (d. 2011)
- 1929 – Yayoi Kusama, Japanese artist
- 1929 – P. Ramlee, Malaysian actor, director, singer, songwriter, composer, and producer. (d. 1973)
- 1930 – Derek Bok, American lawyer and academic
- 1930 – Pat Robertson, American minister and broadcaster, founded the Christian Broadcasting Network
- 1930 – Stephen Sondheim, American composer and songwriter
- 1931 – Burton Richter, American physicist and academic, Nobel Prize laureate (d. 2018)
- 1931 – William Shatner, Canadian actor
- 1931 – Leslie Thomas, Welsh journalist and author (d. 2014)
- 1932 – Els Borst, Dutch physician and politician, Deputy Prime Minister of the Netherlands (d. 2014)
- 1932 – Larry Evans, American chess player and journalist (d. 2010)
- 1933 – Abolhassan Banisadr, Iranian economist and politician, 1st President of Iran
- 1934 – May Britt, Swedish actress
- 1934 – Sheila Cameron, English lawyer and judge
- 1934 – Orrin Hatch, American lawyer and politician
- 1935 – Lea Pericoli, Italian tennis player and journalist
- 1935 – Frank Pulli, American baseball player and umpire (d. 2013)
- 1935 – M. Emmet Walsh, American actor
- 1936 – Ron Carey, American trade union leader (d. 2008)
- 1936 – Roger Whittaker, Kenyan-English singer-songwriter and guitarist
- 1936 – Erol Büyükburç, Turkish singer-songwriter, pop music composer, and actor (d. 2015)
- 1937 – Angelo Badalamenti, American pianist and composer
- 1937 – Armin Hary, German sprinter
- 1937 – Jon Hassell, American trumpet player and composer
- 1938 – Rein Etruk, Estonian chess player (d. 2012)
- 1940 – Dave Keon, Canadian ice hockey player
- 1940 – Haing S. Ngor, Cambodian-American physician and author (d. 1996)
- 1940 – George Edward Alcorn, Jr. American physicist and inventor
- 1941 – Billy Collins, American poet
- 1941 – Jeremy Clyde, English singer-songwriter and guitarist
- 1941 – Bruno Ganz, Swiss actor (d. 2019)
- 1941 – Cassam Uteem, Mauritian politician, 2nd President of Mauritius
- 1942 – Jorge Ben Jor, Brazilian singer-songwriter
- 1942 – Dick Pound, Canadian lawyer and academic
- 1943 – George Benson, American singer-songwriter and guitarist
- 1943 – Nazem Ganjapour, Iranian footballer and manager (d. 2013)
- 1943 – Keith Relf, English singer-songwriter, guitarist, and producer (d. 1976)
- 1945 – Eric Roth, American screenwriter and producer
- 1946 – Don Chaney, American basketball player and coach
- 1946 – Rivka Golani, Israeli viola player and composer
- 1946 – Rudy Rucker, American mathematician, computer scientist, and author
- 1946 – Harry Vanda, Dutch-Australian singer-songwriter, guitarist, and producer
- 1947 – George Ferguson, English architect and politician, 1st Mayor of Bristol
- 1947 – James Patterson, American author and producer
- 1947 – Maarten van Gent, Dutch basketball player and coach
- 1948 – Andrew Lloyd Webber, English composer and director
- 1949 – Fanny Ardant, French actress, director, and screenwriter
- 1949 – Brian Hanrahan, English journalist (d. 2010)
- 1952 – Des Browne, Scottish lawyer and politician, Secretary of State for Scotland
- 1953 – Kenneth Rogoff, American economist and chess grandmaster
- 1955 – Lena Olin, Swedish actress
- 1955 – Pete Sessions, American politician
- 1955 – Valdis Zatlers, Latvian physician and politician, 7th President of Latvia
- 1956 – Maria Teresa, Grand Duchess of Luxembourg (born María Teresa Mestre y Batista)
- 1957 – Jürgen Bucher, German footballer
- 1957 – Stephanie Mills, American actress and singer
- 1959 – Matthew Modine, American actor, director, producer, and screenwriter
- 1960 – Tarmo Laht, Estonian architect
- 1960 – Lauri Vahtre, Estonian historian and politician
- 1961 – Simon Furman, British comic book writer
- 1963 – Deborah Bull, English ballerina
- 1963 – Susan Ann Sulley, English pop singer (The Human League)
- 1963 – Martin Vizcarra, Peruvian engineer and politician, 67th President of Peru
- 1964 – David Gillespie, Australian rugby league player
- 1966 – Pia Cayetano, Filipino lawyer and politician
- 1966 – Todd Ewen, Canadian ice hockey player and coach (d. 2015)
- 1966 – Artis Pabriks, Latvian academic and politician, 11th Minister for Defence of Latvia
- 1966 – António Pinto, Portuguese runner
- 1966 – Brian Shaw, American basketball player and coach
- 1967 – Mario Cipollini, Italian cyclist
- 1967 – Bernie Gallacher, Scottish-English footballer (d. 2011)
- 1970 – Andreas Johnson, Swedish singer-songwriter
- 1970 – Leontien van Moorsel, Dutch cyclist
- 1970 – Hwang Young-cho, South Korean runner
- 1971 – Keegan-Michael Key, American actor, comedian, and writer
- 1972 – Shawn Bradley, German-American basketball player, coach, and actor
- 1972 – Cory Lidle, American baseball player (d. 2006)
- 1972 – Elvis Stojko, Canadian figure skater and sportscaster
- 1973 – Beverley Knight, English singer-songwriter and producer
- 1974 – Marcus Camby, American basketball player
- 1974 – Philippe Clement, Belgian footballer
- 1974 – Geo Meneses, Mexican producer and singer
- 1975 – Cole Hauser, American actor and producer
- 1975 – Jiří Novák, Czech-Monegasque tennis player
- 1976 – Teun de Nooijer, Dutch field hockey player
- 1976 – Kathryn Jean Lopez, American journalist
- 1976 – Asako Toki, Japanese singer-songwriter
- 1976 – Kellie Shanygne Williams, American actress
- 1976 – Reese Witherspoon, American actress and producer
- 1977 – Joey Porter, American football player and coach
- 1977 – Tom Poti, American ice hockey player
- 1979 – Aaron North, American guitarist
- 1979 – Juan Uribe, Dominican baseball player
- 1981 – Arne Gabius, German runner
- 1982 – Piá, Brazilian footballer
- 1982 – Enrico Gasparotto, Italian cyclist
- 1982 – Michael Janyk, Canadian skier
- 1984 – Piotr Trochowski, German footballer
- 1985 – Mayola Biboko, Belgian footballer
- 1985 – Jakob Fuglsang, Danish cyclist
- 1985 – Mike Jenkins, American football player
- 1985 – Justin Masterson, American baseball player
- 1985 – Kelli Waite, Australian swimmer
- 1986 – David Choi, American singer-songwriter, guitarist, and producer
- 1986 – Dexter Fowler, American baseball player
- 1987 – Ike Davis, American baseball player
- 1987 – Jairo Mora Sandoval, Costa Rican environmentalist (d. 2013)
- 1987 – Liam Doran, British rally cross driver
- 1989 – Ruben Popa, Romanian footballer
- 1989 – J. J. Watt, American football player
- 1989 – Tyler Oakley, American internet celebrity
Deaths on March 22
- 880 – Carloman of Bavaria, Frankish king
- 1144 – William of Norwich, child murder victim
- 1322 – Thomas, 2nd Earl of Lancaster, English politician, Lord High Steward of England (b. 1278)
- 1418 – Dietrich of Nieheim, German bishop and historian (b. 1345)
- 1421 – Thomas of Lancaster, 1st Duke of Clarence, English soldier and politician, Lord High Steward of England (b. 1388)
- 1454 – John Kemp, Archbishop of Canterbury
- 1471 – George of Poděbrady (b. 1420)
- 1544 – Johannes Magnus, Swedish archbishop and theologian (b. 1488)
- 1602 – Agostino Carracci, Italian painter and educator (b. 1557)
- 1685 – Emperor Go-Sai of Japan (b. 1638)
- 1687 – Jean-Baptiste Lully, Italian-French composer and conductor (b. 1632)
- 1758 – Jonathan Edwards, English minister, theologian, and philosopher (b. 1703)
- 1772 – John Canton, English physicist and academic (b. 1718)
- 1820 – Stephen Decatur, American commander (b. 1779)
- 1832 – Johann Wolfgang von Goethe, German novelist, poet, playwright, and diplomat (b. 1749)
- 1840 – Étienne Bobillier, French mathematician and academic (b. 1798)
- 1864 – Konstanty Kalinowski, writer, journalist, lawyer and revolutionary (b. 1838)
- 1881 – Samuel Courtauld, English businessman (b. 1793)
- 1896 – Thomas Hughes, English lawyer and politician (b. 1822)
- 1913 – Song Jiaoren, Chinese educator and politician (b. 1882)
- 1913 – Ruggero Oddi, Italian physiologist and anatomist (b.1864)
- 1924 – William Macewen, Scottish surgeon and neuroscientist (b. 1848)
- 1931 – James Campbell, 1st Baron Glenavy, Irish lawyer and politician (b. 1851)
- 1942 – Frederick Cuming, English cricketer (b. 1875)
- 1942 – William Donne, English captain and cricketer (b. 1875)
- 1945 – John Hessin Clarke, American lawyer and judge (b. 1857)
- 1952 – D. S. Senanayake, 1st Prime Minister of Sri Lanka (b. 1883)
- 1955 – Ivan Šubašić, Croatian lawyer and politician, 23rd Prime Minister of Yugoslavia (b. 1892)
- 1958 – Mike Todd, American film producer (b. 1909)
- 1960 – José Antonio Aguirre, Spanish lawyer and politician, 1st President of the Basque Country (b. 1904)
- 1966 – John Harlin, American mountaineer and pilot (b. 1935)
- 1971 – Johannes Villemson, Estonian-American runner (b. 1893)
- 1971 – Nella Walker, American actress and vaudevillian (b. 1886)
- 1974 – Peter Revson, American race car driver (b. 1939)
- 1974 – Orazio Satta Puliga, Italian automobile designer (b. 1910)
- 1976 – John Dwyer McLaughlin, American painter (b. 1898)
- 1977 – A. K. Gopalan, Indian educator and politician (b. 1904)
- 1978 – Karl Wallenda, German-American acrobat and tightrope walker, founded The Flying Wallendas (b. 1905)
- 1979 – Ben Lyon, American actor and studio executive (b. 1901)
- 1981 – James Elliott, American runner and coach (b. 1915)
- 1981 – Gil Puyat, Filipino businessman and politician, 13th President of the Senate of the Philippines (b. 1907)
- 1986 – Olive Deering, American actress (b. 1918)
- 1986 – Mark Dinning, American singer (b. 1933)
- 1987 – Odysseas Angelis, Greek general and politician (b. 1912)
- 1989 – Peta Taylor, English cricketer (b. 1912)
- 1990 – Gerald Bull, Canadian engineer and academic (b. 1928)
- 1991 – Léon Balcer, Canadian lawyer and politician, 19th Solicitor General of Canada (b. 1917)
- 1991 – Paul Engle, American novelist, poet, playwright, and critic (b. 1908)
- 1991 – Dave Guard, American singer-songwriter and guitarist (b. 1934)
- 1991 – Gloria Holden, English-American actress (b. 1908)
- 1993 – Steve Olin, American baseball player (b. 1965)
- 1994 – Dan Hartman, American singer-songwriter, and producer (b. 1950)
- 1994 – Walter Lantz, American animator, director, and producer (b. 1899)
- 1996 – Don Murray, American drummer (b. 1945)
- 1996 – Robert F. Overmyer, American colonel, pilot, and astronaut (b. 1936)
- 1996 – Billy Williamson, American guitarist (b. 1925)
- 1999 – Max Beloff, Baron Beloff, English historian and academic (b. 1913)
- 1999 – David Strickland, American actor (b. 1969)
- 2000 – Carlo Parola, Italian footballer and manager (b. 1921)
- 2001 – Stepas Butautas, Lithuanian basketball player and coach (b. 1925)
- 2001 – Sabiha Gökçen, Turkish soldier and pilot (b. 1913)
- 2001 – William Hanna, American animator, director, producer, and voice actor, co-founded Hanna-Barbera (b. 1910)
- 2001 – Robert Fletcher Shaw, Canadian businessman, academic, and civil servant (b. 1910)
- 2002 – Rudolf Baumgartner, Swiss violinist and conductor (b. 1917)
- 2003 – Terry Lloyd, English journalist (b. 1952)
- 2004 – Janet Akyüz Mattei, Turkish-American astronomer and academic (b. 1943)
- 2004 – Ahmed Yassin, Co-founded Hamas (b. 1937)
- 2004 – V. M. Tarkunde, Indian lawyer and civil rights activist (b. 1909)
- 2005 – Rod Price, English guitarist and songwriter (b. 1947)
- 2005 – Gemini Ganesan, Indian film actor (b. 1920)
- 2005 – Kenzō Tange, Japanese architect, designed the Yoyogi National Gymnasium and Hiroshima Peace Memorial Museum (b. 1913)
- 2006 – Pierre Clostermann, French soldier, pilot, and politician (b. 1921)
- 2006 – Pío Leyva, Cuban singer and author (b. 1917)
- 2006 – Kurt von Trojan, Austrian-Australian journalist and author (b. 1937)
- 2007 – U. G. Krishnamurti, Indian-Italian philosopher and educator (b. 1918)
- 2008 – Cachao López, Cuban-American bassist and composer (b. 1918)
- 2010 – James Black, Scottish biologist and pharmacologist, Nobel Prize laureate (b. 1924)
- 2010 – Özhan Canaydın, Turkish basketball player and businessman (b. 1943)
- 2011 – Artur Agostinho, Portuguese journalist (b. 1920)
- 2011 – Victor Bouchard, Canadian pianist and composer (b. 1926)
- 2012 – Joe Blanchard, American football player and wrestler (b. 1928)
- 2012 – John Payton, American lawyer and activist (b. 1946)
- 2012 – Matthew White Ridley, 4th Viscount Ridley, English academic and politician, Lord Lieutenant of Northumberland (b. 1925)
- 2012 – Mickey Sullivan, American baseball player and coach (b. 1932)
- 2012 – David Waltz, American computer scientist and academic (b. 1943)
- 2012 – Neil L. Whitehead, English anthropologist and author (b. 1956)
- 2013 – Vladimír Čech, Czech actor and politician (b. 1951)
- 2013 – James Nabrit, American lawyer and academic (b. 1932)
- 2013 – Bebo Valdés, Cuban-Swedish pianist and composer (b. 1918)
- 2013 – Derek Watkins, English trumpet player and composer (b. 1945)
- 2013 – Ray Williams, American basketball player and coach (b. 1954)
- 2014 – Yashwant Vithoba Chittal, Indian author (b. 1928)
- 2014 – Mickey Duff, Polish-English boxer and manager (b. 1929)
- 2014 – Thor Listau, Norwegian soldier and politician (b. 1938)
- 2014 – Tasos Mitsopoulos, Cypriot politician, Cypriot Minister of Defence (b. 1965)
- 2015 – Arkady Arkanov, Ukrainian-Russian actor and playwright (b. 1933)
- 2015 – Horst Buhtz, German footballer and manager (b. 1923)
- 2015 – George Neel, Jr., American businessman (b. 1930)
- 2015 – Norman Scribner, American pianist, composer, and conductor (b. 1936)
- 2016 – Phife Dawg, American rapper (b. 1970)
- 2016 – Rob Ford, Canadian businessman and politician, 64th Mayor of Toronto (b. 1969)
- 2016 – Rita Gam, American actress (b. 1927)
- 2018 – Johan van Hulst, Dutch politician, academic and author, Yad Vashem recipient (b. 1911)
Holidays and observances on March 22
- Bihar Day (Bihar, India)
- Christian feast day:
- Basil of Ancyra
- Blessed Clemens August Graf von Galen
- Darerca of Ireland
- Epaphroditus
- Jonathan Edwards (Lutheranism)
- Lea of Rome
- Nicholas Owen
- Paul of Narbonne
- March 22 (Eastern Orthodox liturgics)
- Earliest day on which Easter Sunday can fall (last in 1818, will not happen again until 2285), while April 25 is the latest. (Christianity)
- Emancipation Day or Día de la Abolición de la Esclavitud (Puerto Rico)
- World Water Day (International)