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When horse serum is injected intravenoulsy in to a rabbit and again in to the skin two or three weeks later, what is the necrotizing reaction that occurs as the site of the second injection________________?

When horse serum is injected intravenoulsy in to a rabbit and again in to the skin two or three weeks later, what is the necrotizing reaction that occurs as the site of the second injection________________?

A. Atopy
B. Anaphylaxis
C. Arthus phenomenon
D. Serum sickness