What important event(s) occur(s) in John Milton’s “Paradise Lost” immediately after Eve first eats of the Tree of Knowledge ?

What important event(s) occur(s) in John Milton’s “Paradise Lost” immediately after Eve first eats of the Tree of Knowledge ?

A. Nature is immediately wounded by Eve’s transgression.
B. Satan is immediately wounded by Eve’s transgression.
C. Raphael is immediately wounded by Eve’s transgression.
D. Abdiel immediately flees the Council of Rebel Angels.