The Jacobean era ended with a severe economic depression in 1620-1626, complicated by a serious outbreak of ____________in London in 1625 ?

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The Jacobean era ended with a severe economic depression in 1620-1626, complicated by a serious outbreak of ____________in London in 1625 ?

A. Cholera
B. Tuberculosis
C. Bubonic plague
D. Plague (disease)