Disease Associated with Immune System

Question: A monoclonal antibody (mAb) specific for the 2,4-dinitrophenyl (DNP) hapten might also bind
[A].

Leu or Ileu

[B].

His or Pro

[C].

Tyr or Phe

[D].

Ser or Thr

Answer: Option C

Explanation:

No answer description available for this question.

Question: Difficulties with somatic gene therapy arise from all of the following except
[A].

GVHD caused by mature T cells in the transplanted cells

[B].

inserting a gene so that it will function properly

[C].

limited life span of more mature hematopoietic cells

[D].

transducing genetic material into stem cells

Answer: Option A

Explanation:

No answer description available for this question.

Question: Bone marrow given to an infant with SCID must
[A].

be irradiated to eliminate GVHD

[B].

contain mature T cells that can begin making immune responses immediately

[C].

come from a donor that shares some MHC alleles with the recipient

[D].

come from one of the child’s parents

Answer: Option C

Explanation:

No answer description available for this question.

Question: A selective IgA deficiency would be expected to result in problems with
[A].

bacterial infections

[B].

infections following dental work due to bacteria entering the bloodstream

[C].

mucosal pathogens

[D].

pathogens which can survive inside macrophages

Answer: Option C

Explanation:

No answer description available for this question.

Question: DiGeorge’s syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a
[A].

knock-out mouse for RAG-1 and RAG-2

[B].

knock-out mouse for a thymus

[C].

nude mouse

[D].

recombinant mouse for CD3

Answer: Option C

Explanation:

No answer description available for this question.

Question: X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be
[A].

activation of B cells by T-independent antigens

[B].

failure of B cells to provide co-stimulation for Th2 activation

[C].

failure of Th2 cells to provide co-stimulation for B cell isotype switching

[D].

failure of Th2 cells to provide co-stimulation for B cell proliferation

Answer: Option C

Explanation:

No answer description available for this question.

Question: Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with
[A].

CTL killing of viruses

[B].

dendritic cell activation to become a mature APC

[C].

infected cell processing of virus peptides

[D].

macrophage intracellular killing of bacteria

Answer: Option D

Explanation:

No answer description available for this question.

Question: Infants are most susceptible to bacterial infection due to low circulating levels of IgG
[A].

in utero (before birth)

[B].

at 0-3 months of age

[C].

at 3-12 months of age

[D].

at 12-24 months of age

Answer: Option C

Explanation:

No answer description available for this question.

Question: If Class IIMHC is not expressed in the thymus, the resulting immune deficiencies would include all of the following except reduced
[A].

alternative complement activation.

[B].

CD8 T cell-mediated cytotoxicity

[C].

macrophage activation to vesicular pathogens

[D].

IgG synthesis

Answer: Option A

Explanation:

No answer description available for this question.

Question: Combined cellular and humoral immune deficiencies result from lack of all of the following except
[A].

a thymus

[B].

class II MHC

[C].

HIV infection of CD4+ T cells

[D].

transporter of antigen peptides (TAP)

Answer: Option D

Explanation:

No answer description available for this question.