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Which of the following mechanism explains development of anemia in Renal failure?

Which of the following mechanism explains development of anemia in Renal failure?

A. Failure of bone marrow is accompanied with renal failure.
B. Destruction of RBC results from accumulated urea in the blood.
C. Chronicity of the disease is respobsible for anemia
D. Failure of proper RBC synthesis, due to lack of chemical stimulation.