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Reversible pulpitis change to irreversible pulpitis primarily because of:__________?

/ Medical Mcqs, Oral Pathology and Medicine, Pulp And Periapical Infections / By
Reversible pulpitis change to irreversible pulpitis primarily because of:__________?

A. Vacular strangulation
B. Reduced host resistance
C. Invasion of microorganisms
D. An increase in microbial virulence